Mike Ezuruonye attended the Federal Government College, Wukari, Taraba, and Archbishop Aggey Memorial School, Lagos. He studied Accounting at Nnamdi Azikiwe University in Anambra State, Nigeria. Before becoming an actor, he worked as a banker. Ezuruonye has appeared in numerous Nollywood movies and received a Best Actor in a Leading Role nomination for his performance in the movie "The Assassin" at the Africa Movie Academy Awards in 2009, as well as a nomination for Best Actor in the Africa Magic Viewers Choice Awards.